Objectives: Drug addiction and withdrawal are associated with maladaptive changes in brain reward and inhibitory circuits, leading to emotional and cognitive impairments. This study aimed to investigate whether acupuncture at Shenmen (HT7) points modulates specific neural circuits to attenuate alcohol- and cocaine-related behaviors, and to identify the underlying neurobiological mechanisms. Methods: Using alcohol-dependent and cocaine-treated animal models, we examined the behavioral and neurochemical effects of HT7 acupuncture. Behavioral analysis included alcohol withdrawal tremor, anxiety like behaviors, alcohol self-administration, and cocaine-induced locomotor activity. Neurophysiological and neurochemical changes were assessed by β-endorphin measurements in the nucleus accumbens (NAc), in vivo extracellular recordings, dopamine release monitoring, and optogenetic or lesion-based manipulation of specific brain regions, including the arcuate nucleus (ARC), rostromedial tegmental nucleus (RMTg), lateral habenula (LHb), and medial prefrontal cortex (mPFC). Results: HT7 acupuncture in alcohol -dependent rats attenuated withdrawal tremor, anxiety-like behaviors, and alcohol self-administration, while restoring β-endorphin levels in the NAc and reactivating ARC β-endorphin neurons. In cocaine models, HT7 acupuncture reduced cocaine-induced locomotor activity and NAc dopamine release via activation of RMTg GABAergic neurons, effects that were abolished by RMTg silencing or LHb–RMTg pathway lesions. Additionally, acupuncture increased mPFC neuronal firing and engaged glutamatergic projections to the LHb, suppressing cocaine-induced behaviors and dopamine release; these effects were blocked by mPFC lesions or mPFC LHb pathway inhibition. Conclusion: Acupuncture at HT7 modulates multiple brain circuits—ARC–NAc β-endorphinergic projections, LHb RMTg GABAergic pathways, and mPFC–LHb glutamatergic connections—to suppress drug- and alcohol-related behaviors. These findings suggest that acupuncture may serve as a novel therapeutic strategy for substance use disorders by restoring inhibitory control over mesolimbic reward systems, thereby alleviating emotional and cognitive dysfunctions associated with addiction and withdrawal.