With the growing global interest in Traditional Chinese Medicine (TCM), the standardization and digital transformation of TCM diagnostic devices have become essential for clinical integration and international collaboration. This talk highlights key standardization efforts under ISO/TC249 and other technical committees, focusing on devices for tongue imaging, pulse sensing, and acupoint impedance measurement. By leveraging modern technologies such as near-infrared spectroscopy, electrical impedance analysis, and image recognition, the core concepts of the “Four Diagnostic Methods” (inspection, auscultation/olfaction, inquiry, and palpation) are being translated into quantifiable, sensor-based frameworks. The presentation will also showcase the author’s applied experience in the development of the “TCM Diagnosis and Prescription Engine”—a TCM intelligent diagnosis platform. This system integrates data from tongue, pulse, facial, and inquiry diagnostics to construct syndrome differentiation models and prescribe classical herbal formulas with built-in safety monitoring. Demonstration cases include space station health modules and retail terminals, reflecting how standardization supports TCM modernization and clinical scalability.